Generally, traveling on a plane is safe. Yet, some unpleasant side effects that come with putting your body in a tube and sending it 35,000 ft above the ground can be inevitable.

As long as your flight isn’t delayed or canceled, you might be either feeling excited or stressed about reaching your next travel destination. But no matter what feelings you’re experiencing, certain things could still happen to your body anyway.

One thing you should be really concerned about is that being stuck on a plane with so many other people can put you at risk of catching bacteria and viruses, which could make you sick, especially when the airline’s cabin air is dry and the seating is cramped.

Now, check out the 10 things flying on a plane can do to your body, in addition to practical advice on how to prevent such problems.